Abstract
A series of bicyclic pyrimidinone-based HCV NS3 protease inhibitors was synthesized via selective C8 position functionalization. Substituted phenylamides and phenylureas were preferred in the S2 binding pocket.
MeSH terms
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Benzamides / chemistry
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Bridged Bicyclo Compounds / chemical synthesis*
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Bridged Bicyclo Compounds / pharmacology
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Drug Design
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Humans
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Inhibitory Concentration 50
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Phenylurea Compounds / chemistry
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Pyrimidinones / chemical synthesis*
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Pyrimidinones / pharmacology
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Serine Endopeptidases / metabolism
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Serine Proteinase Inhibitors / chemical synthesis*
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Serine Proteinase Inhibitors / pharmacology
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Stereoisomerism
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Structure-Activity Relationship
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Viral Nonstructural Proteins / antagonists & inhibitors*
Substances
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Antiviral Agents
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Benzamides
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Bridged Bicyclo Compounds
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NS3 protein, hepatitis C virus
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Phenylurea Compounds
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Pyrimidinones
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Serine Proteinase Inhibitors
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Viral Nonstructural Proteins
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Serine Endopeptidases